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Cetaphil

Cetaphil Healthy Radiance Renewing Cream

  • Size: 48 fl oz
  • Key Ingredients: niacinamide,retinol,vitamin b3
  • Item Form: Cream
  • Free Of: Oil Free

Last refreshed Aug 4, 2026 · Based on the Amazon listing and published specifications, not hands-on testing.

Our verdict

A large, hypoallergenic Cetaphil cream combining niacinamide and retinol, sized for high-volume use rather than a trial.

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ASIN: B093VNVYJTCategory: Moisturizers

Overview

Cetaphil's 0299.011601 moisturizer is a fragrance-free, oil-free cream formulated with niacinamide and retinol, packaged at a large 48.01 fluid ounce size in a tube and marked hypoallergenic.

At just over 48 ounces, this is a pump or bulk-scale size rather than the smaller tubes Cetaphil typically sells at retail, worth confirming before buying if you expected a standard bottle. Combining niacinamide with retinol in one cream is a fairly active formulation for a moisturizer, pairing a brightening ingredient with an anti-aging one rather than being a purely basic barrier cream. Hypoallergenic and oil-free labeling points it at sensitive or acne-prone skin that still wants those actives.

  • Size: 48.01 fluid ounces
  • Key ingredients: niacinamide, retinol, vitamin B3
  • Oil-free and hypoallergenic
  • Unscented, tube container

Who it's for

People who want niacinamide and retinol in a single daily moisturizer and go through cream fast enough to justify the large size. Not practical for someone who wants to sample a small tube first or has skin unaccustomed to retinol.

Pros and cons

Pros
  • Combines niacinamide and retinol in one cream
  • Oil-free, hypoallergenic formula
  • Large 48 oz size reduces reorder frequency
Cons
  • Retinol can irritate skin unaccustomed to it
  • Large size is a big commitment if untested first

Performance notes

Retinol is an active ingredient that increases cell turnover and can cause irritation or purging when skin isn't used to it, so pairing it with niacinamide, which has some soothing and brightening properties, is a common way to balance a formula's tolerability. Oil-free and hypoallergenic labeling suggests the base cream is built to minimize additional irritation, but retinol tolerance still varies person to person enough that a new user should expect an adjustment period regardless of the base formula.

Specifications

BrandCetaphil
Dimensions & fit
Size48 fl oz
Capacity & performance
Age RangeAdult
Construction & materials
MaterialHypoallergenic
Other details
Key Ingredientsniacinamide,retinol,vitamin b3
Item FormCream
Free OfOil Free
ScentUnscented
ContainerTube

Frequently asked questions

What active ingredients are in the Cetaphil 0299.011601 moisturizer?

Niacinamide, retinol, and vitamin B3.

How large is this Cetaphil moisturizer?

48.01 fluid ounces, a bulk size rather than a standard retail tube.

Is the Cetaphil 0299.011601 moisturizer oil-free?

Yes, it's labeled oil-free and hypoallergenic.