Vetoquinol Zylkene Calming Supplement Large Dogs 450 mg
- Product Benefits: Calming Support
- Item Form: Capsule
- Dog Breed Size: Large
- Target Species: Dog
Last refreshed Aug 4, 2026 · Based on the Amazon listing and published specifications, not hands-on testing.
A milk-protein-derived calming capsule dosed for large dogs, aimed at situational stress like moving or storms rather than daily sedation.
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ASIN: B00GSWIKOCCategory: Pet Calming Aids
Overview
A calming capsule for large dogs between 33 and 132 pounds, built on alpha-casozepine derived from milk protein, sold as 30 capsules at 450mg each.
Zylkene's active ingredient is alpha-casozepine, sourced from bovine milk protein, positioned as an alternative to melatonin-based calming products. Vetoquinol markets it for stress tied to moving, travel and thunderstorms, not just general anxiety. The capsule is flavorless and sized specifically for the 33 to 132 pound weight range.
- 30 capsules, 450mg each
- For large dogs, 33-132 lbs
- Alpha-casozepine, milk protein derived
- Targets moving, travel, thunderstorm stress
Who it's for
Owners of large dogs facing a specific stressor, a move, storm season, or travel, who want a milk-protein-based calming option rather than melatonin. Not sized for small or medium dogs given the 33-pound minimum.
Pros and cons
- Alpha-casozepine active ingredient, milk-protein derived
- Dosed specifically for large dogs, 33-132 lbs
- 30-count supply lasts about a month at daily dosing
- Not sized for small or medium dogs
- Rating sits slightly lower at 3.9
Performance notes
The formula's calming action comes from alpha-casozepine rather than melatonin, and Vetoquinol frames it around discrete stress events like relocation or thunderstorms. At 30 capsules for a daily-use product, the supply covers roughly a month before reordering.
Specifications
| Brand | Vetoquinol |
|---|---|
| Dimensions & fit | |
| Dog Breed Size | Large |
| Item Weight | 0.05 poundslower than 89% of 28 pet calming aids |
| Capacity & performance | |
| Volume | 169.1 fl oz |
| Included components | |
| Unit Count | 30 |
| Included Components | Vetoquinol Zylkene 450mg (30 Capsules) |
| Other details | |
| Product Benefits | Calming Support |
| Item Form | Capsule |
| Target Species | Dog |
| Pet Type | Dog |
| Flavor | Flavorless |
| Number Of Items | 1 |
| Specific Uses For Product | Anxiety, Moving, Stress, Thunderstorms |
| Asin | B00GSWIKOC |
| Manufacturer | Vetoquinol |
| Best Sellers Rank | #10,516 In Pet Supplies (See Top 100 In Pet Supplies) #110 In Dog Relaxants |
| Customer Reviews | {'ratings_count': '1,005', 'stars': '3.9'} |
| Upc | 017030340853 615867813269 |
| Model Number | Zylkene Caps 450 |
| Manufacturer Part Number | Zylkene Caps 450 |
| Active Ingredients | Hydrolized Milk Protein (bovine) Providing Alpha-Casozepine, FD&C Blue #1 (capsule), Hypromellose (capsule), Magnesium Stearate, Maltodextrin, Titanium Dioxide (capsule) |
Closest rivals on specs
HomeoPet Anxiety Relief for Dogs and Cats 15 ml- Item Weight 0.05 vs 0.06 pounds (-17%)
Purina Pro Plan Veterinary Supplements Calming Care 30 Count- Item Weight 0.05 vs 0.07 pounds (-29%)
Frequently asked questions
What is alpha-casozepine?
It is a compound derived from bovine milk protein that Vetoquinol uses as the calming active ingredient in Zylkene.
What weight range is this sized for?
It is formulated for large dogs between 33 and 132 pounds.
How long does one box last?
The box contains 30 capsules, which covers about a month at one capsule per day.