Proferrin ES- 10.5mg of high Absorbing Heme Iron Polypeptide. Made in the USA. 90…
- Iron
- Tablet
- Iron
- 90
A gut-friendly heme iron option for people who've had trouble with standard iron supplements or take medication that interferes with iron absorption.
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How it ranks among the 59 iron we track
4.5★ across 1,200 Amazon ratings, Bayesian-smoothed toward the category average.
1,200 Amazon ratings, weighted on a log scale so huge counts don't drown everything.
1,000+ bought on Amazon last month.
Brand identity, imagery, description and spec coverage.
The ProductDome score is separate from the Amazon rating shown above: it combines the Bayesian-smoothed Amazon rating with evidence volume, tracked demand, and data quality across the 59 iron we track - how the scorecard works · full iron data report. Confidence: high - strong rating volume and complete data.Last refreshed Aug 4, 2026. Data-computed, not a hands-on test. Compiled by the ProductDome Research Team.
Overview
Proferrin ES is a heme iron polypeptide supplement providing 10.5 mg of iron per tablet, made in the USA in a 90 tablet bottle, positioned as easier on the digestive system than standard iron supplements.
The distinguishing claim on this one is that heme iron polypeptide isn't blocked by coffee, calcium or proton pump inhibitors the way non-heme iron typically is, and that it's gentler on the gut, a common complaint with standard ferrous sulfate. At 10.5 mg per tablet the dose is lower than many standalone iron supplements, so people needing a higher dose may need to take more than one tablet.
- 10.5 mg heme iron polypeptide per tablet
- 90 tablets per bottle
- Made in the USA
- Gluten free
Who it's for
Suited to people who've had trouble tolerating standard iron supplements, including those on PPIs or who drink coffee with meals, since the label specifically calls out that this form isn't affected by those factors. Not the pick for someone who needs a very high single-tablet iron dose.
Strengths and trade-offs
Drawn from this product's published specifications.
- 10.5 mg heme iron per tablet, gentler absorption pathway
- Not blocked by coffee, calcium or PPIs per the label
- Made in the USA
- 10.5 mg per tablet is a modest dose versus some standalone iron products
- No seller description or review data included here
Performance notes
Heme iron polypeptide is absorbed through a different pathway than the non-heme iron in most supplements, which is why the label states it isn't blocked by coffee, calcium or PPIs the way standard iron often is. That absorption route is also the reason it's marketed as gentler on the gut than typical ferrous sulfate tablets.
Specifications
| Brand | Proferrin |
|---|---|
| Form | Tablet |
| Supplement Type | Iron |
| Count | 90 |
| Benefits | Iron Support |
| Flavor | Unflavored |
| Diet | Gluten Free |
| Allergens | Gluten Free |
How it compares
This product against the closest alternatives we track in iron.
| Product | Amazon rating | Ratings | ProductDome score |
|---|---|---|---|
| Proferrin ES- 10.5mg of high Absorbing Heme Iron Polypeptide. Made in the USA. 90…This product | 4.5 / 5 | 1,200 | 4.3 / 5 |
| Nature Made Iron 65 mgNATURE | 4.7 / 5 | 54,615 | 4.6 / 5 |
| Nature's Bounty Iron 65mgNature’s | 4.7 / 5 | 35,600 | 4.6 / 5 |
| Slow Fe 45mg Iron Supplement for Iron DeficiencySlow | 4.7 / 5 | 9,942 | 4.6 / 5 |
| Feosol Original Iron Supplement TabletsFeosol | 4.7 / 5 | 9,100 | 4.6 / 5 |
Similar iron from other brands
Questions about the Proferrin iron
Common buyer questions answered straight from the product spec data - no fluff, no "it depends".
How much iron does each Proferrin ES tablet provide?
Each tablet provides 10.5 mg of heme iron polypeptide.
Does coffee or calcium affect absorption of Proferrin ES?
The label states this heme iron form isn't affected by coffee, calcium or PPIs, unlike standard iron supplements.
How many tablets are in one bottle?
The bottle contains 90 tablets.