Zymox Advanced Formula Otic Plus Enzymatic Ear Solution for Dogs and Cats Without…
- Ear Care
- 100%
- 1
- 1.3 fl oz
- More reviewed than 60%
A straightforward once-daily ear treatment for infections, worth stocking if your vet has ruled out a punctured eardrum and you want to skip the steroid.
As an Amazon Associate, ProductDome may earn a commission from qualifying purchases made through links on this page.
How it ranks among the 63 ear care we track
4.6★ across 1,600 Amazon ratings, Bayesian-smoothed toward the category average.
1,600 Amazon ratings, weighted on a log scale so huge counts don't drown everything.
300+ bought on Amazon last month.
Brand identity, imagery, description and spec coverage.
The ProductDome score is separate from the Amazon rating shown above: it combines the Bayesian-smoothed Amazon rating with evidence volume, tracked demand, and data quality across the 63 ear care we track - how the scorecard works · full ear care data report. Confidence: high - strong rating volume and complete data.Last refreshed Aug 4, 2026. Data-computed, not a hands-on test. Compiled by the ProductDome Research Team.
Overview
Zymox Advanced Formula Otic Plus is an enzymatic ear solution for dogs and cats, formulated in this version without hydrocortisone. It targets ear infections with a once-daily topical routine rather than a course of prescription drops.
The line is built around an enzyme system rather than antibiotics, and this Plus version skips the steroid found in some Zymox variants. That makes it a option for owners who want to avoid hydrocortisone but still need daily infection management. The listing does not include clinical claims beyond usage instructions, so treat it as a topical aid rather than a diagnosis-and-cure product.
- 1.25 fl oz bottle
- Hydrocortisone-free enzymatic formula
- Once-daily application for 7 to 14 days
- For both dogs and cats
Who it's for
Owners of dogs or cats with diagnosed ear infections who want a hydrocortisone-free option they can apply at home. Not intended for pets with a ruptured or punctured eardrum.
Strengths and trade-offs
Drawn from this product's published specifications.
- No hydrocortisone in this formula version
- Single daily application, no separate cleaning step required first
- Labeled safe for extended use on chronic ear issues
- Not usable if the eardrum is punctured
- Applied to an un-cleaned ear, which some owners may find counterintuitive
- Small 1.25 oz bottle for a multi-week course
Performance notes
The bottle is shaken and applied directly onto the un-cleaned ear, filling the canal, then massaged in and wiped of excess. Amazon's listing specifies once a day for 7 days for standard cases or 14 days for chronic issues, and states the formula is meant to be safe for extended use on persistent cases.
Specifications
| Brand | ZYMOX |
|---|---|
| Model | 1201AF |
| Dimensions & fit | |
| Item Weight | 0 ounces |
| Size | 1.2 ounces |
| Item Dimensions L X W | 10 × 10 inches |
| Capacity & performance | |
| Age Range Description | Adult |
| Construction & materials | |
| Fabric Type | 100% |
| Color | Black |
| Included components | |
| Unit Count | 1.3 fl oz |
| Other details | |
| Number Of Items | 1 |
| Model Number | 1201AF |
| Model Name | ZYMOX PLUS ADVANCED FORMULA OTIC DOG AND CAT EAR INFECTION SOLUTION |
| Item Type Name | Item |
| Asin | B072DVND3Z |
| Product Care Instructions | Shake well before use. Apply liberally to un-cleaned ear, filling the ear canal. Gently massage and work into affected area. Wipe to remove excess. Apply once a day for 7 days or 14 days for chronic issues. This product is safe for extended use on persistent cases. Do not use on punctured ear drums. Keep out of reach of children. |
| Theme | Animals |
| Manufacturer | Lambert Vet Supply |
| Recommended Uses For Product | ear infections |
| Additional Features | Hydrocortisone-free |
| Best Sellers Rank | #16,560 in Pet Supplies (See Top 100 in Pet Supplies) #15 in Cat Ear Care #150 in Dog Ear Care |
| Customer Reviews | {'ratings_count': '1,658', 'stars': '4.6'} |
| Upc | 667334421255 |
| Blanket Form | Comforter |
| Manufacturer Part Number | 1201AF |
Other ZYMOX ear care
How it compares
This product against the closest alternatives we track in ear care.
| Product | Amazon rating | Ratings | ProductDome score |
|---|---|---|---|
| Zymox Advanced Formula Otic Plus Enzymatic Ear Solution for Dogs and Cats Without…This product | 4.6 / 5 | 1,600 | 4.3 / 5 |
| Pet MD Dog Ear Cleaning WipesPET | 4.6 / 5 | 63,112 | 4.6 / 5 |
| Nutri-Vet Ear Cleanse for DogsNutri-Vet | 4.6 / 5 | 9,700 | 4.5 / 5 |
| Vetnique Oticbliss Dog Ear Infection Treatment Flush & Ear Cleaner for Dogs & CatsVetnique | 4.6 / 5 | 3,383 | 4.5 / 5 |
| TrizULTRA+Keto FlushTrizULTRA+Keto | 4.7 / 5 | 1,689 | 4.5 / 5 |
Similar ear care from other brands
Questions about the ZYMOX 1201AF
Common buyer questions answered straight from the product spec data - no fluff, no "it depends".
Does Zymox Otic Plus contain hydrocortisone?
No, this is the hydrocortisone-free version of the Zymox Advanced Formula Otic Plus line.
How long do you use Zymox 1201AF for a chronic ear issue?
The product instructions call for once-daily application for 14 days on chronic or persistent cases, versus 7 days for standard use.
Should the ear be cleaned before applying this solution?
No, the instructions direct you to apply it to the un-cleaned ear, filling the canal, then wiping away excess after massaging it in.