Differin Acne Treatment Gel
- Gel
- 15 fl oz
- All, Sensitive
- Bottle
- More reviewed than 94%
A 0.1% adapalene retinoid gel for acne-prone skin, sized for a 30-day course and requiring consistent use before results show.
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How it ranks among the 238 gels we track
4.4★ across 8,300 Amazon ratings, Bayesian-smoothed toward the category average.
8,300 Amazon ratings, weighted on a log scale so huge counts don't drown everything.
Modest tracked demand last month.
Brand identity, imagery, description and spec coverage.
The ProductDome score is separate from the Amazon rating shown above: it combines the Bayesian-smoothed Amazon rating with evidence volume, tracked demand, and data quality across the 238 gels we track - how the scorecard works · full gels data report. Confidence: high - strong rating volume and complete data.Last refreshed Aug 4, 2026. Data-computed, not a hands-on test. Compiled by the ProductDome Research Team.
Overview
Differin Acne Treatment Gel is an over-the-counter retinoid formulated with 0.1% adapalene, sold as a 15g pump meant to last about 30 days of once-daily use. It targets acne and is made by Galderma Laboratories.
Adapalene is the same retinoid class ingredient long available by prescription before Differin's switch to over the counter, and it works over weeks rather than days, so the 30-day supply size matches its typical use pattern rather than being an arbitrary trial size. The oil-free, fragrance-free, non-comedogenic formulation is built for acne-prone skin that still needs to avoid clogging pores further.
- 15g pump, roughly a 30 day supply
- 0.1% adapalene retinoid gel
- Oil free, fragrance free, non-comedogenic
- Made by Galderma Laboratories
Who it's for
Fits people managing ongoing acne who want a retinoid gel rather than a spot treatment, applied to the whole face nightly. Not for anyone expecting fast results, since retinoids typically take several weeks to show a visible change.
Strengths and trade-offs
Drawn from this product's published specifications.
- 0.1% adapalene retinoid, the over-the-counter strength active
- Oil free and non-comedogenic
- Takes weeks of consistent use to show results
- Retinoid adjustment period can bring dryness or peeling
Performance notes
Adapalene works by normalizing the shedding of skin cells inside the pore lining, which reduces new clogged pores forming over time rather than treating existing breakouts directly. That mechanism is why retinoid gels like this one are applied preventively across the whole face rather than dabbed onto individual spots, and why initial dryness or peeling during the first weeks is common as skin adjusts.
Specifications
| Brand | Differin |
|---|---|
| Model | 0299.491010 |
| Dimensions & fit | |
| Item Weight | 1.8 ounces |
| Capacity & performance | |
| Item Volume | 15 fl oz |
| Construction & materials | |
| Material Features | Oil Free, Alcohol Free, Fragrance Free, Non Comedogenic |
| Other details | |
| Skin Type | All, Sensitive |
| Container Type | Bottle |
| Asin | B07ZTMXJVK |
| Special Ingredients | Retinoid |
| Customer Reviews | {'ratings_count': '8,355', 'stars': '4.4'} |
| Model Number | 0299.491010 |
| Item Form | Gel |
| Upc | 302994910106 |
| Active Ingredients | Adapalene 0.1% |
| Item Type Name | Retinoid |
| Manufacturer | Galderma Laboratories, Inc |
| Scent Name | Unscented |
| Product Benefits | Anti-Acne |
| Manufacturer Part Number | B07ZTMXJVK |
| Set Name | Differin Gel Acne Treatment |
| Target Use Body Part | Face |
Other Differin gels
How it compares
This product against the closest alternatives we track in gels.
| Product | Amazon rating | Ratings | ProductDome score |
|---|---|---|---|
| Differin Acne Treatment GelThis product | 4.4 / 5 | 8,300 | 4.2 / 5 |
| Simple Kind to Skin Refreshing Facial Wash GelBrand | 4.6 / 5 | 28,500 | 4.6 / 5 |
| patanjali Aloe Vera Gelpatanjali | 4.4 / 5 | 7,300 | 4.5 / 5 |
| Bioderma Sensibio Foaming Gel Gentle Face CleanserBioderma | 4.7 / 5 | 22,700 | 4.3 / 5 |
| Nature Republic Mild & Moisture Aloe Vera Watery GelNature Republic | 4.6 / 5 | 13,200 | 4.1 / 5 |
Similar gels from other brands
Questions about the Differin 0299.491010
Common buyer questions answered straight from the product spec data - no fluff, no "it depends".
How long does one Differin 15g pump last?
It is sized as roughly a 30-day supply with once-daily use.
Is Differin Gel oil free?
Yes, the formula is oil free and non-comedogenic.
What is the active ingredient in Differin Gel?
Adapalene at 0.1%, a retinoid.